But Alvaro DOMINGUEZ wasted a chance, keeper Justo VILLAR saved, and Colombia were punished.
Roque SANTA CRUZ was left with a lot of space in a counter-attack and easily scored when keeper Miguel CALERO was trying to close the striker's angle.
And with 19 seconds gone into the second half, SANTA CRUZ was on the run again. Inter defender, Iván CORDOBA couldn't keep up with Roque's pace and the Bayern Munich striker doubled the lead for Argentine Gerardo MARTINO's team.
With 35 minutes into the second half, SANTA CRUZ recorded the first hat-trick of the Copa so far and substitute Salvador CABAÑAS scored a brace to give Paraguay a sensational 5-0 win that leaves them in great shape to face the USA in their next game.
Paraguay and Colombia share Group C with Argentina.